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The effect of caffeinated versus decaffeinated drinks on overactive bladder: a double-blind, randomized, crossover study

机译：含咖啡因与不含咖啡因的饮料对膀胱过度活动症的影响：一项双盲，随机，交叉研究

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Purpose: the primary aims of this study were to test the methodology for use in a future randomized control trial and to investigate the effect of drinking caffeinated versus decaffeinated fluids on symptoms of overactive bladder (OAB) in women.Design: a double-blind, randomized, crossover study was conducted.Methods: fourteen community-dwelling women newly diagnosed with OAB and a history of caffeine consumption were randomly allocated to group A (14-day caffeinated drink period followed by 14-day decaffeinated drink period) or group B (14-day decaffeinated drink period followed by 14-day caffeinated drink period). The periods were preceded by a 14-day run-in period and interspersed with a 14-day washout period. Primary outcomes were episodes of urgency, frequency, volume per void, and incontinence obtained each period on 3-day bladder diaries. Secondary outcome measures were OAB symptom severity and health-related quality of life (QOL) recorded each period using International Consultation on Incontinence–Overactive Bladder Module (ICIQ-OAB) and ICIQ-OAB–Quality of Life (ICIQ-OABqol) tools. Effects of caffeine reduction were measured each day using visual analogue scales.Results: eleven participants completed the study. A significant reduction in urgency (P < .01) and frequency (P < .05) of urinary voids on day 3 of the diary, total ICIQ-OAB score (P < .01), and a non-significant directional change for the total ICIQ-OABqol score (P = .065) was found using sign tests for the period of decaffeinated compared to caffeinated drink intake. No significant differences were found for any caffeine withdrawal measures.Conclusions: despite the small sample size, this pilot study demonstrated that reducing caffeine intake may alleviate the severity of some symptoms and health-related QOL factors associated with OAB. Furthermore, caffeine substitutes were well tolerated
机译：目的：本研究的主要目的是测试用于将来的随机对照试验的方法，并研究饮用含咖啡因和不含咖啡因的液体对女性膀胱过度活动症（OAB）症状的影响。设计：双盲，方法：将14名刚诊断出患有OAB且有咖啡因消费史的社区妇女随机分配到A组（14天含咖啡因的饮料期，然后是14天脱咖啡因的饮料期）或B组（ 14天不含咖啡因的饮料期，然后是14天不含咖啡因的饮料期）。在此之前先进行14天的磨合期，再穿插14天的清除期。主要结局是在3天的膀胱日记中每个时期出现的尿急，发作频率，每个空隙的体积和大小便失禁。次要结局指标是使用失禁-膀胱过度活动国际咨询（ICIQ-OAB）和ICIQ-OAB-生活质量（ICIQ-OABqol）工具在每个时期记录的OAB症状严重程度和与健康相关的生活质量（QOL）。每天使用视觉模拟量表测量咖啡因减少的效果。结果：11名参与者完成了研究。日记第3天的尿急迫切性（P <.01）和尿频（P <.05）显着降低，ICIQ-OAB总得分（P <.01），并且尿道的方向无明显变化使用符号测试发现与不含咖啡因的饮料摄入量相比，不含咖啡因的时期的ICIQ-OABqol总得分（P = .065）。结论：尽管样本量很小，但这项初步研究表明，减少咖啡因摄入量可能减轻与OAB相关的某些症状和与健康相关的QOL因子的严重程度。此外，咖啡因替代品耐受性良好

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